Security analysts and representatives of portfolio management firms may contact:

Kathee Littrell, Ph.D., RN Vice President, Investor Relations (650) 225-1034

Sue Morris, Ph.D. Director, Investor Relations (650) 225-6523

Diane Schrick Senior Manager, Investor Relations (650) 225-1599

Individual investors and brokers may contact:

Carmen Orton Senior Specialist, Investor Relations (650) 225-1260

Diane Schrick Senior Manager, Investor Relations (650) 225-1599

Contact Genentech's Transfer Agent
Communication regarding transfer requirements, lost certificates and changes of address should be directed to:

Computershare Trust Company, N.A.
c/o Computershare Investor Centre
P.O. Box 43078
Providence, RI 02940-3078
Attn: Shareholder Inquiries
Telephone: (800) 733-5001
www.computershare.com